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Use of Cariprazine in Bipolar Affective Disorder

B.A. Antonovich
Moscow Research Institute of Psychiatry - Branch of the V.P. Serbsky National Medical Research Center of Psychiatry and Narcology of the Ministry of Health of the Russian Federation, Moscow, Russia

Treatment of bipolar affective disorder has a number of difficulties: despite the availability of mood stabilizers, it is not always possible to achieve rapid intermission. This review focuses on studies of cariprazine, a new antipsychotic drug, for bipolar disorder. The article describes the mechanism of action of the drug, the results of placebo-controlled and comparative randomized clinical trials, as well as data from two meta-analyzes evaluating the efficacy and tolerability of cariprazine. Comparative characteristics of cariprazine and other antipsychotic drugs used in therapy of bipolar disorder are given. Based on recent research, practical recommendations have been provided to use of cariprazine in patients with bipolar disorder.


CITATION: Antonovich B.A. Use of Cariprazine in Bipolar Affective Disorder // Sovrem. ter. psih. rasstrojstv [Current Therapy of Mental Disorders]. – 2021. – No. 1. – P. 34–43. – DOI: 10.21265/PSYPH.2021.46.92.005 [in Russian] 
CONFLICT OF INTEREST: the author declare no conflict of interest. 

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