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Influence of Functional Asymmetry on Treatment of Schizophrenia

E.M. Sychugov, L.N. Kasimova, O.S. Zaitsev
Federal State Budgetary Educational Institution of Higher Education “Privolzhsky Research Medical University” of the Ministry of Health of the Russian Federation, Nizhniy Novgorod, Russia

Summary: The results of modern studies confirm the importance of assessing the individual profile of functional asymmetry in patients with schizophrenia, however, the question of the influence of lateralization on the effectiveness of the treatment of the disease remains under-researched.
Materials and methods: 92 patients with a diagnosis of schizophrenia were examined. The features of the individual profile of functional asymmetry of each patient were determined and the effectiveness of the conducted psychopharmacotherapy was evaluated.
Results: Patients with a symmetric profile of functional asymmetry are characterized by a high frequency of exacerbations requiring psychiatric hospital readmissions, as well as a high incidence of extrapyramidal side effects. The superiority of the degree of asymmetry of motor functions over the auditory-speech ones with their general left hemispheric lateralization is a prognostically favorable factor in the effectiveness of therapy.
Conclusions: Identifying the features of functional asymmetry may contribute to the personification of psychopharmacotherapy of schizophrenia.
Contact: Kasimova Lala, E-mail: kasimovaln@inbox.ru
https://orcid.org/0000-0003-2701-6742
Sychugov Evgeny, E-mail: sychugovem@gmail.com
https://orcid.org/0000-0002-6204-5445 

Citation: Sychugov E.M., Kasimova L.N., Zaitsev O.S. Influence of Functional Asymmetry on Treatment of Schizophrenia // Sovrem. ter. psih. rasstrojstv [Current Therapy of Mental Disorders]. – 2020. – No. 4. – P. 22–27. – DOI: 10.21265/PSYPH.2020.69.26.003 [in Russian] 
Conflict of interest: the authors declare no conflict of interest.
 

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References: 

1.    Barnett K.J., Corballis M.C., Kirk I.J. Symmetry of callosal information transfer in schizophrenia: a preliminary study // Schizophr Res. – 2005. Vol. 74 (2-3). – P. 171–178. 
2.    Luchins D.J., Meltzer H.Y. A blind, controlled study of occipital cerebral asymmetry in schizophrenia // Psychiatry Res. – 1983. –Vol. 10. – P. 87–95.
3.    Stephan-Otto C., Lombardini F., Núñez C. et al. Fluctuating asymmetry in patients with schizophrenia is related to hallucinations and thought disorganization // Psychiatry Res. – 2020. – Vol. 285. – P. 112816. – DOI: 10.1016/j.psychres.2020.112816
4.    Damme K.S.F., Vargas T., Calhoun V. et al. Global and specific cortical volume asymmetries in individuals with psychosis risk syndrome and schizophrenia: A mixed cross-sectional and longitudinal perspective // Schizophr Bull. – 2019, Oct 18. – PII: sbz096. – DOI: 10.1093/schbul/sbz096
5.    Bleich-Cohen M., Hendler T., Kotler M., Strous R.D. Reduced language lateralization in first-episode schizophrenia: an fMRI index of functional asymmetry // Psychiatry Res. – 2009. – Vol. 171. – P. 82–93.
6.    Bilder R.M., Wu H., Bogerts B. et al. Absence of regional hemispheric volume asymmetries in first-episode schizophrenia // Am J Psychiatry. – 1994. –Vol. 151. – P. 1437–1447. 
7.    Robinson D.G., Woerner M.G., McMeniman M., Mendelowitz A., Bilder R.M. Symptomatic and functional recovery from a first episode of schizophrenia or schizoaffective disorder // Am J Psychiatry. – 2004. – Vol. 161. – P. 473–479.
8.    Renoult L., Prévost M., Brodeur M. et al. P300 asymmetry and positive symptom severity: a study in the early stage of a first episode of psychosis // Schizophr Res. – 2007. – Vol. 93. – P. 366–373.
9.    Falkai P., Schneider T., Greve B., Klieser E., Bogerts B. Reduced frontal and occipital lobe asymmetry on the CT-scans of schizophrenic patients. Its specificity and clinical significance // J Neural Transm Gen Sect. – 1995. – Vol. 99. – P. 63–77.
10.    Hsiao M.C., Lin K.J., Liu C.Y., Tzen K.Y., Yen T.C. Dopamine transporter change in drug-naïve schizophrenia: an imaging study with 99mTc-TRODAT-1 // Schizophr Res. – 2003. – Vol. 65. – P. 39–46.
11.    Kasimova L.N., Sychugov E.M., Dorofeev E.V., Zaitsev O.S. Funktsional'naya asimmetriya i endogennye psikhicheskie zabolevaniya. // Psikhicheskoe zdorov'e. – 2018. –T. 16, № 2 (141). – S. 14–25.
12.    Vostryakov V.M., Uranova N.A. Vozmozhnaya svyaz' narusheniya mezhpolusharnoi asimmetrii pri shizofrenii so snizheniem chisla perineironal'nykh oligodendrotsitov // Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. – –2016. –– T. 116, № 8. –– S. 70–73.
13.    Sychugov E.M, Kasimova L.N, Zaitsev O.S. Svyaz' psikhopatologicheskikh osobennostei u bol'nykh shizofreniei s individual'nym profilem funktsional'noi asimmetrii // Sibirskii vestnik psikhiatrii i narkologii. – 2019. – № 1 (102). – S. 28–36. – DOI: 10.26617/1810-3111-2019-1(102)-28-36
14.    Ob"edkov V.G., Teterkina T.I. Iskhody shizofrenii v kontekste individual'nogo profilya funktsional'noi asimmetrii golovnogo mozga // Psikhicheskoe zdorov'e. – 2014. – № 9. – S. 48––55.
15.    Bochkarev V.K., Kirenskaya A.V., Tkachenko A.A., Samylkin D.V., Novototskii-Vlasov V.Yu., Kovaleva M.E. Chastotnye i prostranstvennye kharakteristiki elektroentsefalogrammy bol'nykh paranoidnoi shizofreniei v zavisimosti ot vyrazhennosti produktivnoi i negativnoi simptomatiki // Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. – 2015. – № 115 (1). – S. 66–74. – DOI: 10.17116/jnevro20151151166-74
16.    Sychugov E.M., Dorofeev E.V., Senina E.N., Samylina M.S., Kravchenko Yu.S., Mitrofanova A.I. Vyrazhennost' shizotipicheskikh proyavlenii i osobennosti funktsional'noi asimmetrii golovnogo mozga. // Meditsinskii al'manakh. – 2018. – № 5 (56). – S. 153–159