CORRECTORS OF EXTRAPYRAMIDAL SYMPTOMS AND COGNITIVE DISORDERS IN SCHIZOPHRENIA: PROBLEMS AND SOLUTIONS
SUMMARY: This review addresses the problem of the use of anticholinergic drugs and their effects on the cognitive functioning of patients. It provides an overview of the literature on the effects of discontinuation of these drugs. The results of our own research on cognitive functioning of 31 patients with paranoid schizophrenia (F20.0) and the impact of the use of trihexyphenidyl on cognitive function are presented. Patients with paranoid schizophrenia showed impaired visual-motor short – and long-term memory and executive functioning. The presence of EPS leads to certain impaired cognitive functions in patients with paranoid schizophrenia, which causes the necessity of their correction with anticholinergic drugs. It is possible to draw a conclusion about the advisability of preferential prescription of second generation antipsychotics and short courses of anticholinergic drugs with the transition to antipsychotics with better tolerability.