Status message

Not the entire site translated, but only to "Journal"

Clinical experience with cariprazine in schizophrenic patients with exacerbation of psyсhotic symptoms

Moscow Research Institute of Psychiatry – Branch of the V.P. Serbsky National 
Medical Research Center of Psychiatry and Narcology of the Ministry of Health of the Russian Federation, Moscow, Russia
Abstract. There are still some unmet needs in schizophrenia treatment like the persistence of negative symptoms and unsatisfactory tolerability of antipsychotic therapy. This report is showing two clinical cases of schizophrenia exacerbation that required acute treatment. All of them were successfully treated with cariprazine. In the first case patient also had predominant positive symptoms. There were signs of therapy resistance and poor tolerance to most antipsychotics in the second case. 
CITATION: Tsukarzi E. Clinical experience with cariprazine in schizophrenic patients with exacerbation of psyсhotic symptoms // Sovrem. ter. psih. rasstrojstv [Current Therapy of Mental Disorders]. – 2021. – No. 2. – P. 47–51. – DOI: 10.21265/PSYPH.2021.57.2.006
CONFLICT OF INTEREST: this work was carried out with a sponsorship from Gedeon Richter Pharma LLC.

It appears your Web browser is not configured to display PDF files. Download adobe Acrobat or click here to download the PDF file.


1.    Mosolov S.N. Osnovy psikhofarmakoterapii. – M.: Vostok, 1996. – 288 s. 
2.    Biologicheskie metody terapii psikhicheskikh rasstroistv. Dokazatel'naya meditsina – klinicheskoi praktike / pod red. S.N. Mosolova. – M.: Sotsial'no-politicheskaya mysl', 2012. – 1073 s.
3.    Huhn M., Nikolakopoulou A., Schneider-Thoma J., Krause M., Samara M., Peter N., Arndt T., Bäckers L., Rothe P., Cipriani A., Davis J., Salanti G., Leucht S. Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis // Lancet. – 2019. – Vol. 394. – Pp. 939–951. DOI: 10.1016/ S0140-6736(19)31135-3 
4.    Krause M., Zhu Y., Huhn M. et al. Antipsychotic drugs for patients with schizophrenia and predominant or prominent negative symptoms: a systematic review and meta-analysis // Eur Arch Psychiatry Clin Neurosci. – 2018. – Vol. 268 (7). – P. 625–639.
5.    Mosolov S.N., Tsukarzi E.E. Psikhofarmakoterapiya shizofrenii // Psikhiatriya: natsional'noe rukovodstvo / pod red. N.G. Neznanova, Yu.A. Aleksandrovskogo. − M.: Geotar-Media, 2018. – S. 299−328.
6.    Mosolov S.N., Tsukarzi E.E., Alfimov P.V. Algoritmy biologicheskoi terapii shi-zofrenii // Sovremennaya terapiya psikhicheskikh rasstroistv. – 2014. – № 1. – C. 27–36.
7.    Citrome L. Cariprazine for the Treatment of Schizophrenia: A Review of this Dopamine D3-Preferring D3/D2 Receptor Partial Agonist // Clin Schizophr Relat Psychoses. – 2016. – Vol. 10 (2). – Pp. 109–119. 
8.    Karlson A., Lekrub'e I. Dofaminovaya teoriya patogeneza shizofrenii: rukovodstvo dlya vrachei / pod red. S.N. Mosolova. – London: Taylor & Francis, 2004.–188 s.
9.    Corponi F., Serretti A., Montgomery S., Fabbri C. Cariprazine specificity profile in the treatment of acute schizophrenia: a meta-analysis and meta-regression of randomized-controlled trials // Int Clin Psychopharmacol. – 2017. – Vol. 32 (6). – Pp. 309–318. 
10.    Németh G., Laszlovszky I., Czobor P., et al. Cariprazine versus risperidone monotherapy for treatment of predominant negative symptoms in patients with schizophrenia: a random-ised, double-blind, controlled trial // Lancet. – 2017. – Vol. 389 (10074). – Pp. 1103–1113.
11.    Marder S., Fleischacker W., Lu K., Zhong Y., Nemeth G., Laszlovszky I., Durgam S. Effi-cacy of cariprazine across symptom domains in patients with acute exacerbation of schizo-phrenia: Pooled analyses from 3 phase II/III studies // Eur Neuropsychopharmacology. – 2019. – Vol. 1. – Pp. 127–139. 
12.    Avrutskii G. Ya., Neduva A. A. Lechenie psikhicheski bol'nykh. – 2-e izd. – M.: Meditsi-na, 1988. – 528 s. 
13.    Mosolov S.N., Tsukarzi E.E., Oleneva E.V., Alfimov P.V. Sovremennye metody preodoleniya terapevticheskoi rezistentnosti pri shizofrenii // Mosolov S.N. Bio-logicheskie metody terapii psikhicheskikh rasstroistv. Dokazatel'naya meditsina – kli-nicheskoi praktike. – M.: Sotsial'no-politicheskaya mysl', 2012. – S. 102–117.