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Non-adherence to antidepressants in recurrent depressive disorder: a review

Alexey Pavlichenko
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Mosciw, Russia

Non-adherence to antidepressants is one of the main reasons of relapses while treating people with recurrent depressive disorder. Review of the articles reporting on the association between non-adherence to antidepressants and outcomes indicates that non-compliant patients are more likely to have an increased risks of relapse, re-hospitalizations, increased severity of depression and decrease in response that can also lead to increase in total healthcare costs associated with depression. Patient-specific barriers and medication side effects as well as acceptability are the major challenges for adhering to treatment. Considering all measures of the particular antidepressant (efficacy, acceptability, cost), sertraline might be the best first choice for treating moderate to severe depression. There is also an unmet need to develop effective interventions to improve adherence to antidepressants. To do so, we should focus not only on clinicians but also nurses and share with patients some printed educational information about depression.

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