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Comparative study of transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT) in therapy-resistant depressions

Tsukarzi E.E., Ilyin S.A., Mosolov S.N.
Federal Medical Research Centre of Psychiatry and Narcology of Ministry of health of the Russian Federation

In a comparative study of high-frequency (15 Hz) transcranial magnetic stimulation (TMS) and electroconvulsive therapy (ECT) has been evaluated their effectiveness in treatment-resistant depression (TRD) (N = 71). It was found that high-frequency TMS and ECT observed similar effect on responders rate in TRD (51.4% / 64.7%), but significantly inferior to TMS in terms of remission (27.0% / 41.1%). ECT was more effective than TMS in treatment of depressions with psychotic symptoms and marked anxiety symptoms. The main marker of the effectiveness of TMS was a young patient age (under 35 years). At follow-up assessment at 3 months noted a decrease differences between the groups due to the increase of responders in the group of patients treated with TMS.

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