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Cognitive Impairment in Bipolar Affective Disorder

A.E.Konoreva, S.N.Mosolov
Federal Medical Research Centre of Psychiatry and Narcology of Ministry of Healthcare of the Russian Federation

Summary. Cognitive changes in bipolar disorder (BD) have been actively studied for the last decades. This article provides an overview of evidence-based research of cognitive impairment in BD, contains analysis ofits’ variability which depends on the stage and severity of the disorder. Various medication effects, primarily mood stabilizers were analyzed; the possible causes of cognitive deficit were examined. Impairment of executive functions, attention and long-term memory could be traced throughout all the phases, including both acute episodes of mania or depression and periods of euthymia. These features may indicate special, genetically determined, neurocognitive endophenotype for BD.

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